Assessment of Optic Nerve Changes in Patients Receiving Anti-Tuberculosis Drugs at Different Time Interval

Objectives: To assess optic nerve changes in patients receiving anti-tuberculosis drugs and to at different time intervals of therapy. Study design settings: Descriptive cross-sectional study was conducted from August 2021 November Madinah Teaching Hospital, Faisalabad. Methodology: 200 eyes 100 therapy since 2-month, 4-month, 6 month 8 months were taken. Patients did not have any systemic disease other than Tuberculosis. Indirect Ophthalmoscopy performed fundus head. Optical Coherence Tomography for assessment retinal fiber layer thickness cup disc ratio. Data analysed by using descriptive statistics chi-square test with SPSS version 20. Results: In 2 there 16(66.66%) normal fundus, 8(33.33%) glaucomatous cupping. 4 months, 12(15.38%) 16(20%) atrophy, neuropathy, 4.00(5%) neuritis 30(38%) 7(21%) 4(12.5%) atrophy 21(50%) neuropathy. 24(36%) 34(51.5%) 4(6%) Glaucomatous dis cupping (P 0.00). Result this also shows that is 83(41.5%), increase 4(2.0%) decrease 113(56.5%). Conclusions: This concluded responsible severity when duration increases